the effect of hla-drb1 on cholecystitis

background: cholecystitis is one of the major digestive diseases. its prevalence is particularly high in some populations. significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes. objective: to determine the association between hla-drb1 and cholecystitis. methods: this casecontrol study included forty iraqi arab patients who had cholecystitis with multiple calculi treated by cholecystectomy admitted in the surgical ward at al-kindy teaching hospital baghdad between september -2013 to june -2014. the control group consisted of forty healthy volunteers among the staff of al-kindy college of medicine. control and cholecystitis patients groups were typed for identifying the drb1* alleles using dna-based methodology (pcr-ssop). results: there was an increased frequency of hla-drb1*0301 in patients with cholecystitis compared with healthy controls (p=0.0442, odd ratio=4.1111, 95% ci: 1.0372-16.2949). conclusion: hladrb1*0301, as a genetic factor, seems to have an association with cholecystitis.